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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG2
All Species:
18.18
Human Site:
Y936
Identified Species:
36.36
UniProt:
P16885
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16885
NP_002652.2
1265
147870
Y936
E
L
S
D
L
V
V
Y
C
K
P
T
S
K
T
Chimpanzee
Pan troglodytes
XP_001147944
1265
147906
Y936
E
L
S
D
L
V
V
Y
C
K
P
T
S
K
T
Rhesus Macaque
Macaca mulatta
XP_001111677
1265
147898
Y936
E
L
S
D
L
V
V
Y
C
K
P
T
S
K
T
Dog
Lupus familis
XP_546812
1252
146274
E929
K
N
Q
S
I
A
I
E
L
S
D
L
V
V
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIH5
1265
147573
Y936
E
L
S
D
L
V
V
Y
C
K
P
T
S
K
T
Rat
Rattus norvegicus
P24135
1265
147716
Y936
E
L
S
D
L
V
V
Y
C
K
P
T
S
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508105
991
115582
K668
V
Y
C
K
P
T
S
K
T
K
D
N
L
E
N
Chicken
Gallus gallus
Q2VRL0
637
72514
K314
I
E
E
T
M
L
R
K
G
R
D
S
H
G
E
Frog
Xenopus laevis
Q32NH8
758
87399
K435
G
K
I
L
L
K
G
K
K
I
G
R
L
E
D
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
N461
L
L
K
G
K
K
L
N
G
L
L
G
K
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624101
1134
132613
I811
G
R
P
D
L
K
W
I
L
R
I
Q
N
P
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
P617
Y
F
E
M
S
S
F
P
E
T
K
V
E
R
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
94.4
N.A.
94.1
94.7
N.A.
62.7
20.7
22.1
21.2
N.A.
N.A.
40.9
N.A.
32.9
Protein Similarity:
100
99.9
99.2
97
N.A.
97.1
97.3
N.A.
67.8
33.2
37.5
34.9
N.A.
N.A.
59.1
N.A.
49
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
6.6
0
6.6
6.6
N.A.
N.A.
13.3
N.A.
0
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
13.3
26.6
13.3
13.3
N.A.
N.A.
33.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
42
0
0
0
0
0
0
% C
% Asp:
0
0
0
50
0
0
0
0
0
0
25
0
0
0
9
% D
% Glu:
42
9
17
0
0
0
0
9
9
0
0
0
9
17
17
% E
% Phe:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
0
% F
% Gly:
17
0
0
9
0
0
9
0
17
0
9
9
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
9
0
9
0
9
0
9
9
0
9
9
0
0
0
0
% I
% Lys:
9
9
9
9
9
25
0
25
9
50
9
0
9
42
0
% K
% Leu:
9
50
0
9
59
9
9
0
17
9
9
9
17
0
0
% L
% Met:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
9
0
0
0
9
9
0
9
% N
% Pro:
0
0
9
0
9
0
0
9
0
0
42
0
0
9
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
9
0
0
0
% Q
% Arg:
0
9
0
0
0
0
9
0
0
17
0
9
0
9
0
% R
% Ser:
0
0
42
9
9
9
9
0
0
9
0
9
42
0
9
% S
% Thr:
0
0
0
9
0
9
0
0
9
9
0
42
0
9
42
% T
% Val:
9
0
0
0
0
42
42
0
0
0
0
9
9
9
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
9
9
0
0
0
0
0
42
0
0
0
0
0
0
17
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _